Dr. Yin Ting , Dr. Ma Aiqing from the School of Pharmacy of GDMU and Prof. Huang Peng from the School of Biomedical Engineering of Shenzhen University collaborated to publish a review paper entitled “Engineering Bacteria and Bionic Bacterial Derivatives with Nanoparticles for Cancer Therapy” in the internationally renowned journal Small(JCR MATERIALS SCIENCE Q1, top journal, impact factor: 13.281). Guangdong Medical University is the first affiliation for correspondence. Dr. Ma Aiqing and Prof. Huang Peng are the corresponding co-authors. Dr. Yin Ting, a high-level talent introduced to our university and Diao Zhenying , an undergraduate student from the School of Pharmacy, are the co-first authors of this paper.

Bacteria-based therapies are promising candidates for the treatment of malignant tumors due to the capability of targeting the tumor site and triggering the host anti-tumor immunity.Recently, the combination of nanotechnology and bacteria-based therapies can develop multiple bacteria-based drug delivery system and further improve the abilities of tumor targeting and anti-tumor of bacteria, which accelerates the application of engineered bacteria in the field of cancer therapy and diagnostics. In the review, authors systematically summarize representative studies of bacteria-instructed cancer therapy and their key advantages. The current challenges and future prospects in advancing the development of bacteria-based therapies in the field of synthetic biology research are also emphasized, which will hopefully promote the development of related bacteria-based cancer therapies.

 The review paper entitled “Engineering Bacteria and Bionic Bacterial Derivatives with Nanoparticles for Cancer Therapy” was published in Small online(small, 2021, DOI：10.1002/smll.202104643，IF=13.281) , an authoritative publication in the field of materials.

Author:Zhou Zhen

Translator :Yin Ting

Editor:Tang Zhipeng